Hiv Functional Cure - Are We Any Closer To It?

Curing Hiv and Aids is the goal-hence the name Hiv Eradication-and further investigate efforts are bringing us ever closer to development that happen. Gene therapy and zinc finger nucleases (Zfns) are avenues being explored now to see if we can truly heal Aids and cure citizen with the disease. The idea behind gene therapy came about after an Aids inpatient was seemingly cured of the disease after receiving donor bone marrow transplant from a man with a chromosomal deletion conferring resistance to Hiv. Doctors are hoping that even if gene therapy doesn't wholly cure Aids, it can stabilize the disease to the point where those with it won't have to take medication. An Hiv functional cure could be on the horizon.

In this kind of research, Zfn are used to artificially disrupt the co-receptor in Cd4 cells that Hiv uses to infect cells. The investigate attempts to acknowledge the following hypothesis: Can modifying an Hiv patient's own Cd4 cells lead to the yield of Hiv-resistant cells in the future? This single receptor is of interest to researchers because there are categorically citizen out there who are defiant to contracting Hiv. About 2% of those of northern European descent have a deletion in the Ccr5 receptor gene that makes many of them roughly defiant to Hiv infection. Could this lead to an Hiv functional cure?

Hiv

In order to test this out, an Hiv inpatient also stricken with leukemia was given a stem cell transplant using donor cells from a man with this rare genetic mutation. This transplant is generally performed on citizen with leukemia, but it had the further advantage of eliminating the patient's Hiv. Let's repeat that-a stem cell transplant cured an Hiv inpatient of his Hiv. Any years later, the inpatient is still Hiv-free. This is astonishing news, but it has flown wholly under the radar.

Hiv gene therapy is a fine scientific breakthrough, and it can lead to an Hiv functional cure in the very near future. By exploiting a rare genetic mutation that only a small percentage of the world's citizen possesses, this could be the news that those who want to rid the world of Hiv forever want to hear.

Of course, comprehensive testing needs to be done in this area, which is why it's so foremost that funding continue for the efforts of the doctors and researchers who devote their time and knowledge toward finding a legitimate cure for Hiv.

Hiv Functional Cure - Are We Any Closer To It?

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